The Dangers of Mixing Alcohol and Antibiotics

However, others did not support this association (103, 117). Given the biologic plausibility, it would be prudent to avoid alcohol with pyrazinamide. The use of alcohol with griseofulvin is not recommended by the National Consumers League, the FDA, or the NIH (4, 5). Package labeling warns that griseofulvin may potentiate the effects of alcohol, resulting in tachycardia and flushing (93). Disulfiram-like reactions have been reported in the literature (94,–96). Reactions can range in severity; one patient required admission to the intensive care unit (97).

What should I avoid eating and drinking with Levaquin?

As these compounds are chemically related, the occurrence of a disulfiram-like reaction with TMP-SMX seems mechanistically plausible. Per package labeling, alcohol did not affect alcohol dehydrogenase in in vitro studies and may be concurrently consumed with secnidazole (73). To our knowledge, there are no data available on the PK/PD or efficacy of metronidazole. Nitroimidazoles are used for parasitic or anaerobic infections (45).

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